বুধবার, ৩১ অক্টোবর, ২০১২

How To Beat The Winter Blues | StyleNest

| by Georgie Travis

THC WebpageBeat the winter blues with these helpful top tips from Dr. Sebastian Winckler.

As the dark nights creep in, many of us can get a case of the winter blues and in some more extreme cases, may even be affected by SAD (Seasonal Affective Disorder). This is caused by a biochemical imbalance in the hypothalamus due to the lack of sunlight in winter and shorter daylight hours. During this time we can often experience a dip in mood but we may experience symptoms such as sleep problems, over eating, anxiety, mood changes, lethargy, loss of concentration and libido.

Well, help is at hand as Dr. Sebastian Winckler lends us his top tips on how to beat those winter blues.

  1. Get out during the daylight hours. Try and take an extended lunch break and go for a brisk walk around the park or sit next to a window to get the most out of the natural daylight. Getting as much natural light as possible helps improve Vitamin D levels, which in turn will help lift your mood
  2. Boost your serotonin and energy levels by eating ?good carbs? such as fruit, vegetables, nuts, fish and seeds as these will help lift your mood but also control your weight. It?s of course common to comfort eat when you are feeling a little low but this will only offer a short term fix so you need to ditch the refined sugary carbs such as cakes, biscuits and white bread
  3. Supplements such as St John?s Wort may help mild levels of seasonal depression ? but it?s worth checking with your doctor as it can interact with other medications. Also try cod liver oil as this strengthens the immune system and improves vitamin D levels which protects against depression
  4. Light therapy has been shown to be effective in many cases. If you?re not getting enough natural light or struggling to wake up in the morning, try using a light box or dawn stimulator. Sitting in front of a light box for a short period everyday can help improve your mood. A dawn stimulator alarm clock can also help you to wake up naturally which in turn helps improve your mood
  5. Exercise is commonly accepted as a more effective treatment for depression than antidepressants. If you don?t want to exercise outside, try a home exercise video of attend a fitness class and get your heart pumping to release happy hormones
  6. Take a break. If you can, try and take a winter sun holiday or swap your summer holiday for a warm, winter trip to sunnier climates. Exposure to sunlight will increase your Vitamin D levels. The body stores and distributes Vitamin D over a 30 day period.

Tips taken from?www.thehealthcounter.com

Brighten up your face, as well as your mood with one of these radiant blushers.

See more in Health And Fitness ?

Source: http://www.stylenest.co.uk/lifestyle/health-and-fitness/how-to-beat-the-winter-blues/

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শনিবার, ২৭ অক্টোবর, ২০১২

Biogen third-quarter profit rises, as does 2012 forecast

(Reuters) - Biogen Idec Inc reported much higher-than-expected third-quarter profit on Thursday on increased sales of its drugs for multiple sclerosis and cancer, and the U.S. biotechnology company raised its full-year earnings forecast.

The results were also helped by lower-than-expected costs, analysts said.

"They put up a nice solid quarter," said RBC Capital Markets analyst Michael Yee. "What's being appreciated in biotech is the consistent beat and raise by all four of the large cap biotechs this week and that's got the sector on the move."

In addition to Biogen, Amgen Inc, Gilead Sciences Inc, and Celgene Corp all reported higher-than-expected third quarter profits and raised their full-year earnings forecasts.

Excluding one-time items, Biogen earned $1.91 per share, topping analysts' average expectations by 31 cents, according to Thomson Reuters I/B/E/S. Biogen shares rose 2.6 percent.

Biogen now expects 2012 earnings of $6.40 per share to $6.50 per share, excluding items, up from its prior view above $6.20.

The company also now expects 2012 revenue growth to be in the mid-to-high single digits in percentage terms, compared with 2011. It had forecast growth in the mid-single digits.

Wells Fargo analyst Brian Abrahams said in a research note the new forecast was in a range that he and Wall Street had expected, adding "and with this quarter's performance seems easily achievable or beatable".

However, most investors are focused on Biogen's experimental oral MS drug BG-12, which is expecting a U.S. approval decision around March, after the Food and Drug Administration earlier this month extended its review of the medicine by three months.

The company told analysts the agency had some questions for which Biogen submitted written responses, but that they did not involve any additional safety analysis. It said the FDA simply needed more time to review the BG-12 data and characterized the delay as the normal course of business. It had previously said the FDA was not seeking any additional data.

Biogen shares have nearly doubled during the last 18 months, driven primarily by enthusiasm over the impressive data for BG-12, also known as dimethyl fumarate. Once approved, BG-12 would be the third oral treatment for the debilitating disease, but based on its safety and efficacy data it is expected to become the industry leader with annual sales in excess of $1 billion, according to analysts. MS affects more than 400,000 people in the U.S., and 2.1 million worldwide, according to the National Multiple Sclerosis Society.

The company told analysts on a conference call it was "well prepared for upcoming product launches" and said costs would likely rise in the fourth quarter as it gets ready to start selling what is seen as by far its most important future growth driver, BG-12.

Biogen also expects to submit an application in the first quarter of 2013 seeking U.S. approval of its promising long-acting treatment for hemophilia B - the less common form of the disorder in which patients lack certain proteins necessary for blood clotting. Hemophilia will be a new market for the company.

Key data on an experimental drug for ALS, also known as Lou Gherig's disease, is expected late this year or early next year, Biogen said.

Biogen's net profit in the third quarter rose to $398 million, or $1.67 per share, from $354 million, or $1.43 per share, a year ago.

Revenue rose 6 percent to $1.39 billion, a tad above Wall Street estimates of $1.38 billion.

Sales of the MS drug Avonex rose 8 percent to $736 million. Biogen reported that its revenue from its other multiple sclerosis treatment Tysabri dipped 1 percent to $275 million.

Irish drugmaker Elan Corp, Biogen's Tysabri marketing partner, previously reported worldwide sales of $404 million for the quarter, with U.S. sales of the infused drug higher than expected, while sales outside the United States fell short of analysts' estimates.

The company said 2,100 new Tysabri patients were added in the third quarter. The medicine is approved for patients who have had an inadequate response to or are intolerant of other MS treatments.

Avonex demand was being driven by the recently available, more convenient pen-like injector for the drug. Biogen said it was seeing significant conversion from the older needle delivery system, and that more than two-thirds of new Avonex patients were using the once-weekly pen injector.

International Avonex sales were $274 million. While the result was strong, it was hurt somewhat by unfavorable foreign exchange rates and price decreases in some markets like Spain and France.

Company revenue for Rituxan, the non-Hodgkin's lymphoma and rheumatoid arthritis drug Biogen co-markets with Roche, rose 8 percent to $288 million.

Biogen Idec shares rose $3.81, or 2.6 percent, to $145.87 in late morning trade on the Nasdaq.

(Reporting by Bill Berkrot; Editing by Gerald E. McCormick, Jeffrey Benkoe and Andrew Hay)

Source: http://news.yahoo.com/biogen-third-quarter-profit-rises-does-2012-forecast-123809895.html

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শুক্রবার, ২৬ অক্টোবর, ২০১২

I'm Going with Obama. | Sunrise Rants

My three year-old said this before I walked out the door this morning. ?I think he meant a sentiment more closely related to ?I?m leaving with Mom now,? but you never know with this kid. ?But, it inspired me, while?everyone?is out endorsing their candidates, I?d like to stop and endorse mine.

I?m going with Obama.

In many ways, albeit with a dose of romance thrown in, my family embodies the typical struggling family in this Post-Bush recession. ?We chose to throw ourselves into it, chasing a dream of living in New York City, which caused us to leave our jobs behind and yet fail to find the same level of gainful employment. ?Thus, we rented out our home, lived with family, leaned heavily on them financially, made cuts, cleared out our retirement, cleared out anything we had, and charged up our credit cards. ?We put off medical treatment and for a time went without coverage because it wasn?t in the budget. We made cross-country moves to find a place to live in which we had no ties to other than that, in this city, Houston, we could be employed and afford to pay our bills. ?We changed from dad being the primary breadwinner to mom, and dad, like many fathers, by default and without expecting it, because a stay-at-home who is now starting up his own business out of his home while he is taking care of two adorable children, who also happen to be the most demanding bosses we have ever known (and also pay the poorest).

We are a friggin? NPR cliche, a dream story to capture the recession in one tidy?sound?bite. Any trend in dealing with the recession you?ve heard about ? we?ve probably been employing that tactic as well.

And that said, I?m still with Obama.

I don?t believe he got us into this mess, but I believe he?pulled off the?triage, stopped the bleeding, and is working to carefully and thoughtfully pull all of us out.

I do believe we will get there. And I believe that the change he promised us was substantive and real, not a quick-fix or a band-aid but real healing for a young society that has still a lot to learn. We?re not that old of a country, y?all.

I believe that the Democratic party cares more about empowering everyone than the Republican party. ?I believe that the Republican party is facing a crisis because of racism,?misogyny? and ultimately fear. ?My understanding of the republican party is that people want to be able to make decisions about their lives and money based on their own values and?worldview. ?Fine. But, I believe they fear allowing others to do the same thing. ?My suspicion is that treating everyone equally and?empowering?others to make decisions contrary to their own beliefs scares the shit out of them. ?It then?becomes?important to control others decisions so that they can?t make?decisions?themselves contrary to their worldview? ?And that?s where the Republican party fails for me ? they want independence for themselves and freedom but not for anyone else. ?Better to take care of self than trust others to take care of you or to even take care of themselves. ?It?s a real gap in logic. ?I want freedom but my freedom means you don?t have freedom to decide this long list of personal, intimate and basic things?

In another direction, I believe the reason?they?don?t trust others to take care of them in return (i.e. trust government) is because they don?t take care of others in the first place, so why would they believe?someone?else would take care of them? So they hate, and you see it in crazy little spurts of racism and women-hating and immigrant bashing all the time. Of course not all Republicans are like this ?and I apologize to those awesome well-meaning people who call themselves Republican and do not hate but?and it?s a big but? it?s the ?but? I have to worry about because it ends up overpowering the rest.

I believe in the party that says it is committed to everyone and has that track record. ?I would like to believe in the basics of republicanism ? that if everyone can decide where to invest their own money, that it will all go to the right place, but I don?t trust the individual in that way. ?Why would Joe Anybody understand the complexity of what his enormous nation of community members needs? Or even fully his own local community? ?I work really hard and don?t have time to think comprehensively about where my money needs to go to support my community members. That?s why we employ the government through our taxes to specialize in thinking about us as a whole and focus on making the whole work.

Government is great. I can go home and rest knowing that my community is being cared for without my active participation on a daily basis. ?It would be overwhelming to me, a concerned and thoughtful citizen, to not pay taxes and instead take responsibility to decide how and where to invest my money. ?Do I pay the city for the roads? The school for the teachers? If I don?t have money, maybe I stop driving and home school. ?Maybe I return to a barter system so I can avoid working entirely. In that situation, chaos would soon reign and every thing would be pay for play and I would stop playing. ?I would also probably be forced to choose to invest in my own family over paying money to others. ?When push comes to shove, a mother will always shove. ?So in short, the ?government keeps me from being an asshole. Conversely, it?s also my job to keep the government from being an asshole too.

I believe the individual will take care of the individual and that the whole is responsible for taking care of the whole. ?We need a government that is looking out for the whole, not the individual?s right to not worry about the?rest? ?The individual does that just fine on his own. ?We need a strong government creating the best conditions for each individual to be empowered to make the decisions for themselves that are?appropriate?for them to make for themselves. ?We don?t need a government telling women they can?t do this, and people who love each other that they can?t do that, and immigrants that, although we use and abuse you, you can?t stay here without fear. ?To me the Republican party is about restriction of rights of others based on morals and religion and hate and fear (except wealth and guns) and the Democratic party is about allowance and evening the playing field. ?Just look at the news and tally the stories of hate and restriction and which party is behind each act. ?It quickly becomes clear and that?s my defense of this tirade, apologies to those whom it offends. Because this country is about life, liberty and happiness for everyone ? I?m with the Democrats.

I?m with Obama.

~

And for the record, the only voter fraud I?ve heard of is disenfranchisement. ?It is now well established that there is no actual problem of people trying to vote when they do not have the right to vote. ?The problem is that people who do have the right to vote are trying to vote ? at least that?s the problem for the conservatives, inspiring all these silly, hateful voter ID laws.

Rant concluded. Have a great day and please don?t fail to vote.

Source: http://sunriserants.com/im-going-with-obama/

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CEOs Tap Political Leaders To Reduce The Federal Deficit

CEOs from some of the nation?s biggest corporations have called on political leaders in Washington to reduce the federal deficit by increasing tax-revenues and cutting spending.

reduce the federal deficit

In a statement signed by more than 80 corporate leaders, the executives said that regardless of who wins control of Congress and the White House in November, the Federal government must include:

?Comprehensive and pro-growth tax reform, which broadens the base, lowers rates, raises revenues and reduces the deficit.?

Heads of companies including AT&T, Bank of America, and Microsoft, among others, put their names to the ?manifesto? that attests tax increases are inevitable ? no matter which party wins on Election Day.

The CEOs believe recommendations of the bipartisan Simpson-Bowles Commission offer an effective framework for a fiscal plan. Those proposals outlined several options, including cutting tax rates for people at all income levels, eliminating some popular tax deductions, and adding them back selectively, as needed.

Among the signatures on the letter urging deficit reduction are:

AT&T ? Randall Stephenson, Chairman & CEO
Bank of America ? Brian T. Moynihan, President & CEO
Boeing ? W. James McNerney, Jr., Chairman, President & CEO
Cisco ? John Chambers, Chairman, President & CEO
General Electric ? Jeffrey Immelt, Chairman & CEO
Goldman, Sachs ? Lloyd Blankfein, Chairman & CEO
JPMorgan Chase ? Jamie Dimon, Chairman & CEO
Microsoft ? Steve Ballmer, CEO
Nasdaq OMX Group ? Robert Greifeld, CEO
NYSE Euronext ? Duncan L. Niederauer, CEO
Partnership for New York City ? Kathy Wylde, President & CEO
Qualcomm ? Dr. Paul Jacobs, Chairman & CEO
Sirius XM Radio ? Mel Karmazin, CEO
Verizon ? Lowell McAdam, Chairman & CEO
Walgreen ? Gregory Wasson, President & CEO

President Obama believes tax increases on high income earners are necessary and fair to reduce the deficit. Mitt Romney backs a tax overhaul that closes loopholes and spurs economic growth, but he is against raising taxes. The CEOs are calling for an overhaul of the tax code to reduce deductions and loopholes and thus generate more revenue than the current tax code.

A balance approach is needed, and these CEOs are making a lot of sense. The deficit cannot be reduced without cutting spending and increasing tax revenues.

Deficit reduction is not just a Washington political issue or something for the leaders of large corporations to worry about. Interest rates are historically low for borrowers seeking startup loans, infusions of working capital, and business lines of credit.

However, the further the U.S. government gets into debt, the higher interest rates for small business borrowing will go. This will be a hindrance to business growth in the future.

I agree with the CEOs, we need politicians in Washington to stop grandstanding and take rational and equitable steps to cut the deficit.

Letter Photo via Shutterstock


About Rohit Arora

Rohit Arora A frequently quoted expert on small business lending and recently named the ?Top Entrepreneur of 2011? by Crain?s New York Business, Rohit Arora is CEO of Biz2Credit, which connects small business owners with 400 lenders, credit rating agencies and service providers. Since 2007, Biz2Credit has secured $400 million in funding for small businesses across the U.S. via its safe, efficient online platform.

?

Source: http://smallbiztrends.com/2012/10/balance-budget-reduce-the-federal-deficit.html

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বৃহস্পতিবার, ২৫ অক্টোবর, ২০১২

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Strategy Analytics: iPad?s Loss Is Android?s Gain In Tablets In An A Lackluster Quarter Of 25M Units Shipped

ipad-with-ipad-miniWith Apple just ending its conference call for its quarterly results, Strategy Analytics has published its numbers on global tablet sales for the quarter. Apple and the iPad remain in the lead with 57% of all shipments, but just as Apple missed sales expectations on the iPad, it also is losing some market share in the tablet market overall, with Android picking up the slack to reach an all-time high of 41% of shipments on overall shipments of just under 25 million units.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/TqJZ1tURWks/

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Samsung Galaxy Note II for T-Mobile review

Samsung Galaxy Note II for TMobile review

The Samsung Galaxy Note II is coming to America, and unlike its predecessor, it's not being as quiet about the move. In a completely unprecedented feat, the mammoth smartphone not only won over the hearts of four national American carriers and one regional network, it did so without having to make sacrifices in its design, specs or even its name. This is a considerable amount of progress when taking into account the fact that only two mobile operators adopted the original Galaxy Note -- the inaugural phablet, if you will -- and they did so months after its global launch. Heck, T-Mobile released its variant of the Note just three months ago, which likely will be a sour point to early adopters for a long time to come.

As you may have seen in our review of the global Note II, there's a reason for all of the buzz circulating around this new flagship device; it's good. It's very good. Once you get used to the idea of a 5.5-inch smartphone with an included stylus S Pen, you'll take heed of the incredibly fast quad-core processor, the latest version of Android, the high-end camera and the litany of other top-notch features that have helped the device become worthy of our praise.

This review, as you see it today, discusses our impressions of T-Mobile's version of the Note II and how it sizes up against the global model (the N7100), but we're changing things up this time around. Since there will be very few differences across the five different versions offered on US carriers, we're simply going to add our reviews of each carrier-specific unit to this space as we go along. The idea is that this review will encompass every Galaxy Note II sold stateside. Enjoy the galleries below, and continue past the break as we dig into Samsung's latest flagship... again.

Background

Samsung Galaxy Note II for TMobile review

Take a quick look at any of the five Galaxy Note II models destined for the US, and then sneak a peek at the N7100 we had the opportunity to review a few weeks ago. Looking at the two from the front or the sides, you won't be able to tell a difference. Flip the phone over, and there's only one telltale sign: the branding. Indeed, Samsung has continually increased its influence over US carriers with each successive flagship device. If you were impressed by the fact that the American editions of the Galaxy S III remained so close in design to its global counterpart, you'll be blown away by what Samsung was able to accomplish with the Galaxy Note II.

What do we mean? Traditionally, the US smartphone market is one of the toughest in the world for an OEM to enter. The four national carriers have held all of the bargaining chips and have a storied history of telling companies it's their way or the highway -- and phone makers would typically bow to their requests. Exclusivity contracts are commonplace here, as mobile operators continually look for ways to gain an edge over their competition. This means Americans rarely get to enjoy the same handsets sold in Europe and Asia -- unless they're willing to switch to a GSM carrier and purchase the phone at full retail price from an importer. (Even then, there was no guarantee it would be fully compatible with your preferred network.)

The Galaxy S III was the first Android smartphone to be sold on all four major networks, under the same name and with a design nearly identical to its international counterpart. It took several years to get to this point, but Samsung had finally established a powerful enough brand to exert leverage over the desires of the carrier. Essentially, the US powerhouses would be at a competitive disadvantage if they chose not to offer the flagship -- and Sammy was dictating the terms. The only upsetting circumstance left was the fact that the global GS3's quad-core Exynos chip wasn't included; it was switched out for a dual-core Qualcomm Snapdragon S4 wafer.

Samsung Galaxy Note II for TMobile review

Fast-forward several months to the US debut of the Galaxy Note II. Surely it will have been tweaked to the whimsy of the carriers, right? Wrong. With the exception of a few carrier-specific limitations (T-Mobile's AWS or Sprint's embedded SIM are prime examples) and the usual smattering of bloatware, what you see on the N7100 is what you get on every single American iteration -- all the way down to the 1.6GHz quad-core Exynos chipset and other silicon parts.

While this may sound like a lengthy lecture on background, it's important to understand because this is a triumph that has never been accomplished on such a large scale. HTC and LG are trying to do the same thing, with the One series and Optimus G respectively, but they haven't quite matched Samsung's prowess yet -- and consumers are the beneficiaries. Instead of being forced to switch carriers just to get a specific phone, you can now stay with your favorite mobile operator and use your dream device. We also hope that it will prompt carriers to focus on creating the best possible network in an effort to entice potential customers.

Hardware

In case you didn't have the chance to venture over to our in-depth review of the global Samsung Galaxy Note II, it's definitely worth a look -- but we'll be happy to go over some of the smartphone's hardware here regardless. We'll cover minor differences between the N7100 and T-Mobile's units later in the review, but for now we're content in stating that the two phones are almost completely identical with only a few carrier-specific modifications.

If you thought the size of the original Note was polarizing enough for the average smartphone user, the Note II will reinforce that idea. You either love the 5.5-inch frame or hate it; there's very little room for middle ground here. However, it at least offers a slightly more comfortable fit when cradled in your hand, thanks to the fact that the phone is narrower than its predecessor (80.5mm vs. 83mm). It has also adopted the same pebble-like design that's found on the Galaxy S III, which makes the Note II slightly thinner (9.4mm vs. 9.7mm) and helps it feel a little less awkward in-hand than the original version, which used the square and slightly blockier GS2 design language.

Samsung Galaxy Note II for TMobile review

As a result of its thinner and narrower frame, one-handed use isn't quite as difficult on the Note II since our medium-sized digits were able to reach across the entire width of the screen. It's still a bit of a stretch, which means your hands will thank you for the extra exercise, but Samsung also manages to alleviate the concern a bit by introducing features that recognize you're not going to be able to use both of your palms at the same time. The onscreen keyboard and dialpad, for example, can scrunch over to either side for easier use when only one hand is available.

The size issue also naturally leads to another potential concern: drops. Large phones are a little more difficult to maintain a solid grip on, after all, so it's natural to worry about what might happen if it slips out of your hand. While tragedies can occur with nearly every handset when it falls onto a hard surface at just the right angle, early drop tests seem to indicate that this won't be as hefty an issue as some of Samsung's past phones. With faux-metal chrome sides and a polycarbonate back cover, the Note II offers a solid construction that's more durable than your typical device.

Samsung Galaxy Note II for TMobile review

When looking at the T-Mobile Note II, you aren't going to notice any change in how the display looks from the global edition. Just like its overseas counterpart, the phone sports a 5.5-inch HD Super AMOLED screen with a resolution of 1,280 x 720 pixels and density of 267ppi. On paper, this is a slight downturn from the original Note, which crammed more pixels (1,280 x 800) into less space, but the sequel is actually a smidge better. We go into a little more detail in our N7100 review, but here's the CliffsNotes version: the old HD Super AMOLED display used a PenTile matrix, while Samsung's latest attempt offers a moderate upgrade to a non-striped BGR layout. This is an interesting compromise between RGBG and RGB, and it fortunately results in a better viewing experience. Granted, we doubt casual observers will notice the difference, but when closely viewing the two side by side, we could see more pixels on the older device. Darks are a little darker on the second-gen model, and colors are just a bit more saturated, too. The viewing angles on the new Note are also great for watching movies, but they're not that much different from the original. With the brightness cranked up above 75 percent, daylight reading was perfectly feasible without straining our eyes.

Above the display sits an RGB LED notification light, proximity sensor and 1.9MP front-facing camera. Below it, you'll see a physical home button flanked by a menu key on the left and back arrow on the right. Moving to the sides, there's a volume rocker on the left, power / standby button on the right and headphone jack and secondary mic on the top. The bottom is reserved for the micro-USB / MHL port, primary mic and a holster for your S Pen.

Samsung Galaxy Note II for TMobile review

The back of the phone is essentially the only place that offers mention of carrier branding; T-Mobile's logo sits prominently below the 8MP camera and LED flash, with the external speaker and the words "Galaxy Note II" in big print near the bottom (this is different from the N7100, which only featured a Samsung logo at the top). Prying open the back cover reveals the 3,100mAh removable battery hanging out with microSDXC and micro-SIM slots, as well as contacts for NFC and wireless charging.

T-Mobile's version of the Note II, also known as the T889, is the only one of the US bunch to exclude support for LTE (for obvious reasons) and add the standard AWS radio and DC-HSPA+ 42 Mbps to the mix. WiFi calling, the feature that lets you cut down on minutes and keeps you from having to worry about reception in your house or office, is also readily included here. Despite rumors (and even T-Mobile's official website) claiming that this particular Note II is equipped with a Qualcomm CPU, we've confirmed on our end that it is indeed the same Exynos 4412 quad-core processor clocked at 1.6GHz as seen on the other devices.

Also, according to the T889's FCC application, the device includes support for LTE bands 4 (AWS) and 17, though this particular set of radios is currently locked on T-Mobile. We're hoping the AWS LTE band will be enabled for us as soon as the network is ready to push ahead with its next-gen technology, but we haven't heard any official word from Magenta about this. Regardless of what happens, we wouldn't put it past hackers Android programming aficionados to come up with a way of taking advantage of this.

We've put together a spec sheet below that details what you can expect to find -- and enjoy -- on T-Mobile's flavor of the Note II.

Galaxy Note II SGH-T889 Galaxy Note II N7100
Dimensions 5.95 x 3.16 x 0.37 inches (151.1 x 80.5 x 9.4 mm) 5.95 x 3.16 x 0.37 inches (151.1 x 80.5 x 9.4 mm)
Weight 6.35 oz. (180g) 6.35 oz. (180g)
Screen size 5.5 inches 5.5 inches
Screen resolution 1,280 x 720 pixels (267ppi) 1,280 x 720 pixels (267ppi)
Screen type HD Super AMOLED (BGR) HD Super AMOLED (BGR)
Battery 3,100mAh 3,100mAh
Internal storage 16GB (at time of launch) 16 / 32 / 64GB
External storage microSDXC (up to 64GB) microSDXC (up to 64GB)
Rear camera 8MP 8MP
Front-facing cam 1.9MP 1.9MP
Video capture 1080p 1080p
NFC Yes Yes
WiFi Dual-band 802.11 a/b/g/n (2.4 / 5GHz) Dual-band 802.11 a/b/g/n (2.4 / 5GHz)
Radios DC-HSPA+ (42Mbps) / UMTS: 850/AWS/1900/2100; GSM / EDGE; LTE disabled HSPA+ (21.6Mbps) / UMTS: 850/900/1900/2100; GSM / EDGE; LTE (in the N7105)
Bluetooth version 4.0 LE (with Apt-X) version 4.0 LE (with Apt-X support)
SoC 1.6GHz quad-core Exynos 4412 1.6GHz quad-core Exynos 4412
RAM 2GB 2GB
MHL Yes, requires Samsung adapter Yes, but requires Samsung adapter
Operating system Android 4.1 Jelly Bean Android 4.1 Jelly Bean
Software

DNP Samsung Galaxy Note II for TMobile review

As we mentioned already, the hardware is largely the same aside from a scant few carrier-specific tweaks. But what about the firmware, which is typically subject to various heaps of bloatware and other network-favored changes? We'd ask you to wipe that surprised look off of your face, but let's be real: you don't have one right now. No shocker exists here; while we can expect the same TouchWiz UI running Android 4.1 Jelly Bean across the board, every carrier gets a little bit of say in which applications and features are added onto its firmware.

It's important for us to first discuss exactly what kind of general software can be found on the Note II. Regardless of which carrier you purchase the Note II on, this will be the first Samsung device that ships with Jelly Bean already running on it. (It's possibly the first US carrier-branded device period, unless the networks push out an update to the Galaxy S III in the very near future.) This means you can take advantage of features like Google Now (accessed by long-pressing the menu key), which is a card-based system in which the phone learns your interests, habits and other information as you use it. You'll also have access to expandable notifications; you can get plenty more details about your notifications just by glancing at it. Offline maps are also available for your perusal on the Note II.

Samsung loves to throw in a full litany of clever features and functionality in an effort to differentiate its UX over what the consumer will find on competing interfaces. Most of them come in quite handy, but even some tenured TouchWiz users may discover that, just like on the Galaxy S III, there's a bit of a learning curve. Loads of gesture controls, S Pen features and other proprietary enhancements are available, which make for a fun experience... once you figure them all out, anyway. Tutorials are available throughout the software, but it will take a while to become familiarized with what's offered, and to find out which ones are actually of real use to you. Be warned: if you purchase this phone, expect frustration for the first couple weeks as you slowly start to get the hang of it.

One of the areas that will take some getting used to is gesture control. Samsung came up with some pretty clever stuff just by taking advantage of the various sensors used in the Note II. This isn't new territory for the company, as we've already seen most of them employed in the GS3. For instance, you can scroll to the top of a screen by double-tapping the top edge of the phone (one of our favorites); tilt to zoom in and out of the screen in the gallery or browser; pan the phone to move icons on the main screen; shake your phone to look for updates; turn over the phone to mute sounds; directly call whatever contact is displayed on the screen; and more. They're quite fancy and chances are you may only find a few of them to be actually useful, but the options are all there just in case you want them.

New to the Jelly Bean TouchWiz experience are a couple new modes. There's Blocking Mode, which is similar to "Do Not Disturb" in iOS 6. For a specific timeframe of your choosing -- 11 PM to 6 AM, as an example -- you can set up a whitelist of allowed contacts and disable certain notifications that come from anyone not on that list. This is a great idea for anyone that doesn't want to wake up several times a night to incoming emails and other non-essential notifications. Another new feature that comes along with Android 4.1 is the much less useful Easy Experience Mode. In a nutshell, this mode is Samsung's way of introducing first-time smartphone users to the confusing world of TouchWiz. When activated, you're taken into a new launcher that offers customizable pages and large easy-to-read widgets. Aside from that, there's not much to differentiate it from TouchWiz, and ultimately ends up feeling more gimmicky than beneficial.

DNP Samsung Galaxy Note II for TMobile review

Samsung has built in a few features that utilize the phone's front-facing camera in a very innovative fashion. Smart Stay, which we highlighted in our review of the GS3, prevents the screen from going dim while you read it. Meanwhile, Smart Rotation (new to the Note II and Jelly Bean) will keep the screen orientation the same so long as your face is vertically aligned with the camera -- even if your body is tilting at an angle. As an example, you can read something on your phone while lying in bed without worrying about the screen moving to landscape mode.

Quick Glance also debuts on the Note II. This particular feature shows you a few basic notifications when you wave your hand over the proximity sensor. In theory, this saves not only time, but battery life, activating only a small portion of the screen whenever you need to check to see if you've missed any calls or messages.

DNP Samsung Galaxy Note II for TMobile review

Popup Video makes an appearance here and it looks even better on the large screen than what we experienced on the Galaxy S III. Choose a video you want to watch, press the popup button on the bottom-right corner of the screen and the movie hovers over half of the display (and you can pinch-to-zoom to adjust the size however you'd like), leaving you free to take care of other tasks while you watch your favorite flick. Other apps take advantage of this multitasking capability, such as Popup Note (activated with your S Pen) and Popup Browser.

On a similar note, the Note II is the first device to feature Samsung's new Multi-Window mode. A long-press of the back button brings up a hideable side menu containing several apps, including YouTube, ChatOn, Gmail, Maps, Internet and so on. Drag and drop one of the apps onto the top half of the screen, and repeat the process to put a second app on the bottom half. As you likely figured, this gives you the opportunity to truly multitask with some of your most-used programs. Features like this do a great job of making use of the ample screen real estate, and in our review of the N7100 we found that the quad-core processor helped keep things amazingly smooth in this dual-monitor-type setup.

Samsung Galaxy Note II for TMobile review


Here's the problem with Multi-Window: it's not going to ship on any of the US models at the time of release. Unfortunately, the N7100 underwent the exact same concern, as the initial shipments didn't come with the feature pre-installed and it wasn't readily available until a firmware update took care of the issue a week or so later. We're still waiting to hear back from Samsung on when we can expect to see Multi-Window domestically, but it's incredibly disappointing to see such a huge feature get completely left out.

T-Mobile software

DNP Samsung Galaxy Note II for TMobile review

T-Mobile did its fair share of decorating TouchWiz with its own stash of ornaments. The usual littering of carrier support apps (T-Mobile My Account, Name ID, TV, Visual Voicemail and so on) are present, as well as a few other programs and home page widgets, but -- to the company's credit -- they can all be disabled. You also get access to a complimentary 50GB of Dropbox storage space for the next two years. Now for a few pieces of bad news: Carrier IQ is enabled, FM radio isn't supported, and, as mentioned earlier, the Multi-Window feature we raved about in our N7100 review doesn't work... at least, not yet.

Pulling down the notification menu, you'll see an ongoing notice that conveniently shows your current usage status for the month. You can keep track of minutes, messages and data here, and it's very clever. However, it's not removable and not everyone will enjoy it hogging up a fair amount of space in the menu when it could easily be added onto the home page as a widget. (It can also be accessed through the T-Mobile My Account app, and data usage can be found in the settings menu, with the usual spread of Android customization alerts.) On a related note, you'll notice a similar notification plastered on your menu whenever WiFi calling is enabled.

This particular iteration of the Note II also includes the racing game Need for Speed Most Wanted. The game comes loaded with support for the MOGA gaming system (read: Bluetooth controller), which will be sold in T-Mobile stores in November -- as well as plenty of other retail locations -- for $50. We haven't yet had the opportunity to play with the MOGA, but we'll be getting our hands on one soon and will update our review after we collect some initial impressions of it.

S Pen

Samsung Galaxy Note II for TMobile review

On the original Galaxy Note, the pen was certainly mightier than the finger. While we can't say it with a surety, the first "phablet" likely wouldn't have been the breakout hit that it was without the assistance of the S Pen, the "don't call it a stylus" stylus that took advantage of the Note's Wacom digitizer. Samsung's taken things another step with its sequel, throwing in a new Wacom slab with greater pressure sensitivity and a pen with much more functionality.

The new S Pen is longer, wider (8mm) and it's flat on the button side, which makes it feel more like you're grasping an old-fashioned pencil -- a trait that a lot of traditional artists will prefer over the first pen. It also offers a slightly larger tip made of rubber, which also helps deliver a similar sensation to that of your run-of-the-mill writing utensil. The additional levels of pressure sensitivity (1,024, as compared to 256) offer up a more accurate drawing experience and even allows for greater variation in how light or dark your doodling turns out without the need to switch brushes every other second.

Samsung Galaxy Note II for TMobile review

Let's dive into the thick of what the S Pen can do on the new Note. The most significant feature gifted to the latest phablet is the hovering functionality. This will be familiar to anyone who has used a Wacom tablet or Bamboo Pad in the last few years. The phone can sense when the pen is just above it, and it will indicate this by showing off a cursor over the exact spot where the stylus is floating. This opens up a whole bunch of possibilities, many of which encompass the Note II's Air View feature. You can scroll up and down through a list or website when you hover the pen over the top or bottom of the screen; you can point it at your inbox or calendar and a popup box provides more details about that particular email or a list of the appointments you have on that given date; hold it over an icon you've never seen and a little box (tooltip) peeks out to tell you what that button does; and you can point your pen at a thumbnail of a photo or video and a larger version of your selection will pop up. (By the way, the preview mode of the Note II's video player shows GIF-like thumbnails of your entire movie collection.)

You can also use the S Pen button when hovering to access various features. For instance, when you're drawing in the S Note app, a quick press of the button will toggle between different brushes, pencils and the eraser; while long-pressing it will pull up Idea Sketch. In this feature, you write down the name of a particular category (or just browse through the list) and a whole bunch of possible illustrations show up for you to choose from. Once you choose one that suits your fancy, it appears in S Note where you can adjust the size and outline style -- and then you can find inspiration from it, trace it for your own purposes or just put some color in between the lines.

Samsung Galaxy Note II for TMobile review

Speaking of the button, there's plenty more you can do with it when the pen is touching the screen. Press and hold to produce an editable screenshot (handy for maps, websites and other things you want to add notes or drawings to before sending it along to a colleague). You can also press and tap the screen twice to bring up Popup Note, or you can clip a specific part of the screen by pressing and circling around the area you want. Diving into it even more, you can hold the button while drawing gestures: an up arrow brings up the menu, a left arrow mimics the phone's back key and zipping the pen straight up the screen will pull up Quick Command. As we mentioned earlier, the hardest part is mastering the lengthy list of various gestures and commands that your S Pen is capable of producing.

Quick Command, by the way, is another useful feature. A familiar-looking handwriting box shows up, prompting you to write a command symbol followed by a keyword. For instance, write "@ Jill" to send an email to Jill; "? [search term]" performs a web search; "# Robert" tells the phone to call Robert; and the list goes on. This is nice from an accessibility standpoint, but we had a difficult time finding a good reason to use this over S Voice, Google voice search or even our own shortcuts. That doesn't mean it's completely pointless; quite the contrary, in fact. The real benefit of this feature is the ability to add your own customized gestures, which turns Quick Command into Samsung's own version of SmartActions or Tasker. As an example, program the phone to turn Blocking Mode and WiFi on while turning off GPS and Bluetooth at the same time -- all by drawing a letter, number or symbol of your choosing.

Samsung Galaxy Note II for TMobile review

In another unique addition to the S Pen experience, the Note II is capable of sensing when the stylus has been taken out of its cradle. It realizes you intend to use the pen, and automatically launches a special home page with several S Pen friendly options. You can also have the phone activate Popup Note once the pen departs the holster, if you desire. On top of this, you're able to tell the device to sound a notification whenever it senses that the pen has drifted too far away from its home.

Before we move on to the next section, we'll point out that the S Pen on T-Mobile's Note II is precisely the same as the global version, and you won't notice any difference in functionality or how it interacts with the digitizer. We assume it will be the same story for the other US models, but we'll update our review after those units arrive at our doorstep.

Camera

DNP Samsung Galaxy Note II for TMobile review

Samsung cameras need very little introduction, since the company's top-end modules typically do a great job of speaking for themselves. The company has opted to go with 8MP sensors ever since the days of the Galaxy S II and -- despite not moving forward in the megapixel war -- it continues to crank out some of the best cameras in the market. The module on the Galaxy Note II (global and T-Mobile) is identical to the one found on the GS3, which means you're up for just about the same experience.

Per TouchWiz protocol, the Note II's camera has legions of various settings to help modify your shots exactly the way you want. Shooting modes like HDR, low light, panorama, smile shot, face detection, buddy photo share and more are included, as well as a "best face" mode, which lets you take a burst shot of your friends or family, and then pick and choose the best face for each person. On top of these features you can enjoy a limited number of ISO options (up to 800 is supported), white balance, metering and exposure / contrast adjustment. Various scenes are available, such as candlelight, text, autumn colors, party, sunset and quite a few more.

Burst shot mode is also available, but there's one limitation that causes some frustration: you can't use the shutter button to lock exposure or focus when this mode turned on. It can be switched off in the settings, of course, but you can't use a toggle switch as one of the customizable shortcuts on the sidebar.

We got exactly what we expected out of the T-Mobile Note II -- nearly identical results as the Galaxy S III and global Note II with very minor differences coming from firmware changes. The resulting images were very well detailed with little noise and weren't overly saturated, especially when compared to the previous Note. We were also satisfied with the dynamic range in our photos, as well as HDR performance. Lowlight shots, when using the Note II's new shooting mode dedicated to the cause, were also among the best we've seen on a phone. We couldn't pick out much noise in the pictures, it does an amazing job of collecting backlight and the LED flash is bright enough to produce natural colors.

The Note II captures 1080p video in MPEG-4 format, with AVC profile 4.0, a bitrate of 17 Mbps and frame rate of 30 fps. Additionally, it's capable of catching high-res still images while you're recording. If you wait until after the video has recorded, you can still grab shots of that footage at the same resolution it was filmed in (in other words, a 1080p video will award you with 1080p stills if you so desire). The specs are all the same in T-Mobile's iteration of the device as well, and we found that it delivers perfectly smooth footage and great audio capture without very much unwanted background noise such as gusts or loud vehicles. We also ran into the same problem with shaky results while panning from side to side, but again, a large part of that is likely happening because it can be difficult to keep perfectly steady.

Performance and battery life

Samsung Galaxy Note II for TMobile review

It was pretty easy to see how we felt about the performance of the Note II in our review of the global edition, because there really wasn't anything negative to say about it. The device sports a 1.6GHz quad-core Exynos 4412 CPU that is supplemented by a Mali-400MP GPU and 2GB RAM. Its only true competitor at the moment is the Qualcomm APQ8064 Snapdragon S4 Pro, which also offers up ridiculously amazing performance (as seen in our review of the LG Optimus G). It's not too often that we feel the need to use Google's choice of words in describing our experience, but using the Note II is definitely buttery smooth, and was an absolute joy to use. Multitasking, Popup Video, the full S Pen experience and everything in between went without a hitch, delivering solid output without stuttering, lags, delays or bugs that are indicative of a subpar processor.

That said, our real-life usage of T-Mobile's Note II is almost exactly the same, which shouldn't be much of a surprise to anyone. Essentially, the only differences you'll see in performance between the N7100 and the US-centric models are going to be software-based; the silicon is identical, so any visible differences would be a result of whatever tweaks were made. Benchmark junkies are going to love what's coming up next -- we've compiled a table of results for your nerdy enjoyment below.

Samsung Galaxy Note II N7100 Samsung Galaxy Note II T889 Samsung Galaxy S III (T-Mobile) LG Optimus G (AT&T)
Quadrant 6,819 6,695 4,853 7,531
Vellamo v2.0 1,831 1,759 1,517 1,704
AnTuTu 13,539 13,602 6,765 11,284
SunSpider 0.9.1 (ms) 1,023 1,059 1,764 1,283
GLBenchmark 2.5 Egypt 1080p Offscreen (fps) 17 17 13 31
CF-Bench 15,267 15,186 8,759 14,372
SunSpider: lower scores are better.


Very few phones take full advantage of the processing power at their disposal, but Samsung's latest Note does its best to push the Exynos chipset to the max. While none of the US models will have Multi-Window upon launch, there are still plenty of other features on the phone that make as much use of all four cores as possible. The ability to have multiple popup apps running simultaneously and still allow you to run other tasks underneath is a true test of the Exynos -- and it passes with flying colors, producing virtually no slowing or lagging during this process. Graphics-intensive gaming is another way to see what the SoC is made of, and a walkthrough of several missions in Dead Trigger showed that it was perfectly capable of handling the load.

The battery life of T-Mobile's model undergoes the same treatment as the phone's performance. It utilizes the same 3,100mAh cell that we enjoyed on the N7100, and with most hardware factors staying the same, the only difference we would see here is in the firmware and how well the carrier has actually optimized it. (The jury's still out on whether or not the LTE-enabled variants will be able to retain the same battery life, but we'll update our review as we get those results.) Our video rundown test, which is our standard benchmark that consists of running a video on an endless loop with the screen at 50 percent brightness, with push email and regular social media notifications enabled, helped us get 11 hours and 30 minutes out of T-Mobile's version. Compared to the N7100's 10:45, it's a solid improvement. Real-life usage proved to be just as legendary as its international compadre, giving us almost two full days with moderate usage.

Call quality was also well above average, even when we found ourselves in areas with less-than-suitable reception. If you're deep in a building with virtually no signal at all, at least T-Mobile's version of the Note II offers WiFi Calling, which may give you a certain advantage over the other networks -- if you're actually in range of an open hotspot, of course. The speakerphone, as expected, was quite loud and perfectly capable for our needs.

Pricing and comparison

Samsung Galaxy Note II for TMobile review

As we mentioned earlier, the benefit of having a flagship phone offered on all four major carriers (and one regional network as well) is that you don't have to worry about switching to a different company if you're a happy customer. Because of this, we get to focus on how the Galaxy Note II sizes up to its competition within each network, rather than judging whether or not it's worth making the jump to somewhere else.

T-Mobile's version of the Galaxy Note II goes on sale today, and you can choose a couple different options: either you can go for the Equipment Installment Plan, which involves an out-of-pocket down payment of $249 and 20 monthly payments of $20 thereafter (available in retail stores), or just go for the classic plan (online and retail) and shell out $369 in exchange for a full two-year commitment. If contracts or monthly installments really aren't your scene, you can grab it at full retail for $649. It's only available in a 16GB option, and T-Mobile hasn't announced any intentions to add a 32GB flavor.

This certainly puts the Note II on the absolute top pricing tier, but this shouldn't come as a surprise to anyone who just looked at the spec sheet. In T-Mobile's case, this will be the first (and so far, only) quad-core device offered by the company. Your only other choices in the company's premium smartphone lineup are the Samsung Galaxy S III ($229 for 16GB, $279 for 32GB) and -- to a lesser extent -- the HTC One S ($150) and Samsung Galaxy S Relay 4G ($150). In other words, Sammy completely owns T-Mobile's upper tier of smartphones. This means that unless you are looking for a QWERTY device, these two devices are your only options; once you narrow it down to that pair, the only factors will be size, power and the amount of interest you have in the S Pen. (Windows Phones are certainly a competitive possibility as well, though we can't speak much on the selection or OS until we know the official details.)

Wrap-up

Samsung Galaxy Note II for TMobile review

For now, this review of the Galaxy Note II is a dynamically changing one. We've only had the opportunity to get a feel of how T-Mobile's version of the device holds up against not only the rest of the carrier's lineup but the N7100 as well, but we've been quite happy to see that very few things have actually been tweaked in the migration to the US. As we mentioned earlier, we'll continue to update this review as we receive the other variants in the mail. But we're confident that our assessment of the global Note II still stands valid with T-Mobile's edition -- and because of this, it currently sits smugly as our top choice in its lineup. That is, unless the size is just too intimidating for you.

Source: http://www.engadget.com/update/samsung-galaxy-note-ii-usa/

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Top Tips For Student Budgeting | Frugal Finance

Budgeting is a massive part of student life. It generally comes as quite a shock to new students who have never had to buy food, household goods or look after themselves in general. It pays to get good at budgeting pretty quick when you get to uni, it really will help you in the long run!

Here are a few of the top tips to make sure your first few months go off without a hitch:

Recording ? In your very first month of university, try to record how much money you spend on what and when. This will help you create an initial budget that can act as a benchmark for the rest of the year. You can also review on which areas you could be skimming the fat.

Books ? Yes the first year of university does come with an inevitable spend on academic literature and there is no way of getting round that. There are though, ways of getting around the premium prices you can find at the high street book stores. First of all, you don?t have to buy every single book on your reading list; many of them will be available from your university library anyway.

But the downside of library borrowing is that a lot of texts are very popular and when it comes to writing an essay, the majority of the people on your course could be scrapping for the same book. In this instance always go for second hand. There is an abundance of online book stores where you can get the literature you need for much cheaper.

Pay off the boring stuff first ? This is a standard rule of thumb and it goes for everyone, not just university students. As long as you have the big stuff, phone bills, utilities, rent etc. covered you shouldn?t get into too much trouble. If you would rather spend your excess money on drinking than going food shopping that?s fine, as long as you?re not evicted from your house!

Mike writes for an essay writing company offering academic services to students around the world called Essay-Site.com.

Source: http://www.frugalfinance.co.uk/top-tips-for-student-budgeting/

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Leading European experts call for more rigorous scientific evidence for healthcare interventions

Leading European experts call for more rigorous scientific evidence for healthcare interventions [ Back to EurekAlert! ] Public release date: 23-Oct-2012
[ | E-mail | Share Share ]

Contact: Emma Knott
Emma.knott@kaizo.net
44-020-731-764-715
European Science Foundation

Leading clinicians and health researchers from across Europe say much greater emphasis must be placed on the scientific evidence for the effectiveness of treatments and other healthcare interventions to ensure patients receive the best care available. The call is contained in a Science Policy Briefing published by the European Medical Research Councils, which also made ten key recommendations on how to improve the quality of research and healthcare in Europe.

The briefing, 'Implementation of Medical Research in Clinical Practice', says that there must be much greater awareness among health professionals of the benefits of health technology assessment (HTA). This is the systematic examination of the safety, effectiveness and cost-effectiveness of the application of a health technology such as a drug, medical device or a clinical or surgical procedure. HTA must become a cornerstone of healthcare.

"It is imperative, morally, socially and economically, that healthcare received by patients in Europe is based on the best scientific evidence," said Professor Liselotte Hjgaard, chair of EMRC. "It is unacceptable for patients to be given treatments which have not been adequately assessed, or to not be offered treatments that have been shown to be the most effective."

The report also argued that a much greater emphasis on systematic reviews of existing evidence for healthcare interventions is required. As such, the scientific evidence for a given treatment or technology must be thoroughly analysed andcomparative effectiveness studies must be carried out on new treatments. If a new drug comes on the market, for example, there must be good evidence that it is more effective and cost-effective than existing treatments before it can be approved for use in publicly funded healthcare services.

Where there are gaps or uncertainties in the current state of knowledge whether a particular treatment is truly effective for example then good quality research must be carried out to answer the question, and the results of such research must be made publicly available. All clinical studies must be rigorously and fully reported, regardless of whether they provide 'positive' or 'negative' results.

Professor Liselotte Hjgaard commented:"Stakeholders must insist on implementing this recommendation as an ethical imperative. Over 50% of clinical studies are never published in full, and more than 30% of trial interventions are not sufficiently well described; there is too much biased under-reporting of studies that have disappointing results."

To achieve these aims it is vital that patients and the public are closely involved in all stages, from making decisions about research priorities to the design of research programmes and clinical trials and the dissemination of the research results.

The briefing also recommends that a European Institute for Health Research be established to provide a forum where issues of common interest in Europe in healthcare research and policy can be debated and appropriate strategies formulated.

###

The Science Policy Briefing resulted from feedback from a wide network of world-class experts in this field and includes detailed case studies on a selected group of countries in Europe. For a copy of the report, please click on this link or contact esf@kaizo.co.uk.

Notes to editors

For more information, please contact

Emma Knott, Kaizo
+44 (0) 207 3176 4715
Emma.knott[at]kaizo.net

About ESF

The European Science Foundation (ESF) is an independent, non-governmental organisation that promotes collaboration in scientific research, funding of research and science policy across Europe. Its members are 79 national funding and research-performing organisations and learned societies from 30 countries. www.esf.org

About EMRC

The European Medical Research Councils (EMRC) is the European Science Foundation's membership organisation for all medical research councils in Europe. The mission of the EMRC is to promote innovative medical research and its clinical application towards improved human health. EMRC offers authoritative strategic advice for science policy making, research management, ethics, and better health services. In its activities, EMRC serves as a voice of its Member Organisations and the European scientific community. EMRC disseminates knowledge and promotes the socio-economic value of medical research to the general public and the decision makers. http://www.esf.org/nc/research-areas/medical-sciences.html



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Leading European experts call for more rigorous scientific evidence for healthcare interventions [ Back to EurekAlert! ] Public release date: 23-Oct-2012
[ | E-mail | Share Share ]

Contact: Emma Knott
Emma.knott@kaizo.net
44-020-731-764-715
European Science Foundation

Leading clinicians and health researchers from across Europe say much greater emphasis must be placed on the scientific evidence for the effectiveness of treatments and other healthcare interventions to ensure patients receive the best care available. The call is contained in a Science Policy Briefing published by the European Medical Research Councils, which also made ten key recommendations on how to improve the quality of research and healthcare in Europe.

The briefing, 'Implementation of Medical Research in Clinical Practice', says that there must be much greater awareness among health professionals of the benefits of health technology assessment (HTA). This is the systematic examination of the safety, effectiveness and cost-effectiveness of the application of a health technology such as a drug, medical device or a clinical or surgical procedure. HTA must become a cornerstone of healthcare.

"It is imperative, morally, socially and economically, that healthcare received by patients in Europe is based on the best scientific evidence," said Professor Liselotte Hjgaard, chair of EMRC. "It is unacceptable for patients to be given treatments which have not been adequately assessed, or to not be offered treatments that have been shown to be the most effective."

The report also argued that a much greater emphasis on systematic reviews of existing evidence for healthcare interventions is required. As such, the scientific evidence for a given treatment or technology must be thoroughly analysed andcomparative effectiveness studies must be carried out on new treatments. If a new drug comes on the market, for example, there must be good evidence that it is more effective and cost-effective than existing treatments before it can be approved for use in publicly funded healthcare services.

Where there are gaps or uncertainties in the current state of knowledge whether a particular treatment is truly effective for example then good quality research must be carried out to answer the question, and the results of such research must be made publicly available. All clinical studies must be rigorously and fully reported, regardless of whether they provide 'positive' or 'negative' results.

Professor Liselotte Hjgaard commented:"Stakeholders must insist on implementing this recommendation as an ethical imperative. Over 50% of clinical studies are never published in full, and more than 30% of trial interventions are not sufficiently well described; there is too much biased under-reporting of studies that have disappointing results."

To achieve these aims it is vital that patients and the public are closely involved in all stages, from making decisions about research priorities to the design of research programmes and clinical trials and the dissemination of the research results.

The briefing also recommends that a European Institute for Health Research be established to provide a forum where issues of common interest in Europe in healthcare research and policy can be debated and appropriate strategies formulated.

###

The Science Policy Briefing resulted from feedback from a wide network of world-class experts in this field and includes detailed case studies on a selected group of countries in Europe. For a copy of the report, please click on this link or contact esf@kaizo.co.uk.

Notes to editors

For more information, please contact

Emma Knott, Kaizo
+44 (0) 207 3176 4715
Emma.knott[at]kaizo.net

About ESF

The European Science Foundation (ESF) is an independent, non-governmental organisation that promotes collaboration in scientific research, funding of research and science policy across Europe. Its members are 79 national funding and research-performing organisations and learned societies from 30 countries. www.esf.org

About EMRC

The European Medical Research Councils (EMRC) is the European Science Foundation's membership organisation for all medical research councils in Europe. The mission of the EMRC is to promote innovative medical research and its clinical application towards improved human health. EMRC offers authoritative strategic advice for science policy making, research management, ethics, and better health services. In its activities, EMRC serves as a voice of its Member Organisations and the European scientific community. EMRC disseminates knowledge and promotes the socio-economic value of medical research to the general public and the decision makers. http://www.esf.org/nc/research-areas/medical-sciences.html



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Source: http://www.eurekalert.org/pub_releases/2012-10/esf-lee102312.php

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A123 Systems, Inc. (NASDAQ:AONE)'s automotive operations goes ...


Shares of A123 Systems, Inc.(NASDAQ:AONE) jumped another 54% to $0.19 in Monday?s session, extending its recovery to 280% from the recent low of $0.05. The automotive operations of A123 Systems, Inc.(NASDAQ:AONE) will be bought by Johnson Controls Inc. The battery maker will be acquiring not just the business assets but also the customer contacts, products and the automotive technology from the Waltham, Massachusetts based company, which specializes in making lithium-ion batteries. Has AONE Found The Bottom and Ready To Move Up? Find Out Here? The Milwaukee, Wisconsin based company will also be getting the company?s Livonia and Romulus facilities in Michigan, the china-based facilities which manufacture cathode power Shanghai Advanced Traction Battery Systems Co.?s equity interests, and the joint venture between A123 Systems and Shanghai Automotive Industry Corporation. The whole deal will cost Johnson Controls about $125 million. Petitions for reorganization under the U.S Bankruptcy Code have already been filed by the company, and its subsidiaries. The company will be receiving an additional amount of $72.5 million, to help the company on, while the sales are still going on. This will be done on the basis of Johnson Controls being a debtor in possession. Since according to the deal and the legalities, the acquisition of A123 Systems is subject to an auction which is to be supervised by the court, the Chinese company, Wanxiang Group wants to buy the business in sale. Wanxiang Group wants to place a higher bid to acquire the company but before the Chinese company puts forward the proposals, it will have to receive the approvals required for the proposals from the Chinese Government, as well as from the Committee on Foreign Investment in the U.S. it is interesting to not that A123 Systems had recently been unable to meet up to orders by Wanxiang Group, worth about $465 million, by failing to get the required permits which were a part of the order. The company had been facing a bad time due to lower number of orders from its chief client, Fisker Automotive. There was less of a demand for hybrids than has been expected, and the company was struggling with finances. However, Johnson Controls is confident about the acquisition because the company believes that alternative technologies and sources of power will soon be in great demand. The acquisition will help spruce up the company?s portfolio, and it will also help with marketing.?

Source: http://themarketsareopen.blogspot.com/2012/10/aone-a123-systems-inc-nasdaqaones-automotive.html

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